Nickel-catalyzed Negishi cross-couplings of 6-chloropurines with organozinc halides at room temperature.
نویسندگان
چکیده
An efficient method for the synthesis of 6-alkyl or 6-aryl purines (nucleosides) was developed via nickel-catalyzed Negishi cross-couplings of 6-chloropurines and organozinc halides. The ligand-free process gave good to excellent isolated yields at room temperature.
منابع مشابه
Nickel-catalyzed enantioselective cross-couplings of racemic secondary electrophiles that bear an oxygen leaving group.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 9 22 شماره
صفحات -
تاریخ انتشار 2011